The full CDC advisory contains detailed background information, clinical observations and data, and guidance for the general public, public health officials, and healthcare providers. The administration credits the increase to its test-to-treat program, which created one-stop hubs in grocery and drug stores where people could take a Covid-19 test and immediately receive and fill a prescription for antiviral medications. People who experience rebound are at risk of transmitting to other people, even though theyre outside what people accept as the usual window for being able to transmit, said Dr. Michael Charness of the Veterans Administration Medical Center in Boston. May 24 (Reuters) - Patients who experience recurrence of COVID-19 symptoms after completing treatment with Pfizer's (PFE.N) drug Paxlovid should isolate again for five days, the U.S. Centers for Disease Control and Prevention said in an advisory issued on Tuesday. COVID-19 Resources for Early Childhood Educators and K-12, Isolation Guidance: Symptom Rebound After Paxlovid, Individuals who have taken Paxlovid for treatment of COVID-19 are reporting recurrence of symptoms following completion of treatment, It is unclear if this is attributed to the treatment and if it differs from the normal course of infection, which has been observed to ebb and flow in some cases since the beginning of the pandemic, Based on available data, COVID-19 rebound is not thought to represent a reinfection with SARS-CoV-2. "We're looking into how we would conduct studies into different, alternative treatment approaches," he said. See here for a complete list of exchanges and delays. In his studies, Charness said, the researchers watched the amount of virus in a persons body called their viral load go down on Paxlovid treatment. <>

CNN Sans & 2016 Cable News Network. Pfizer/Handout via REUTERS. Access unmatched financial data, news and content in a highly-customised workflow experience on desktop, web and mobile. Baby formula shortage: What the US is doing now, Around the nation: NY AG files lawsuit to recover former hospital workers' retirement benefits, CDC now has guidance for those who experience Paxlovid 'viral rebound. (Photo by Mario Tama/Getty Images), Doctor: Covid-19 BA.5 variant is highly transmissible, Dr. Fauci explains why new BA.5 subvariant is concerning, coronavirus variante ba.5 ola contagiosa salud eeuu dusa pkg roa_00004230.png, What you need to know about new Omicron offshoot, The latest (furry) target of Ted Cruz's ire, Vaccines for children under 5 a turning point for many US families, CDC close to decision on Covid-19 vaccine for younger kids, 'Are you gonna let me answer a question? You may experience COVID-19 rebound even if you have not received Paxlovid or other treatment. In the trial that led to Paxlovid's authorization, 2% of those who took the medication and nearly the same percentage of those who didn't experiencedrebounds. "People were repeatedly testing themselves at home, seeing that, along with the resolution of their symptoms, they would have a test that turned negative and then symptoms return and the test becomes positive again.". Individuals with recurrence of COVID-19 symptoms or a new positive viral test after having tested negative should: Paxlovid continues to be recommended for early-stage treatment of mild to modrate COVID-19 among persons at high risk for progression to severe disease. Pfizer'sclinical trialshowed that Paxlovid lowered the risk of hospitalization or death among high-risk COVID patients by 88% within five days of symptoms. COVID-19 rebound is characterized by a recurrence of COVID-19 symptoms or a new positive viral test after having tested negative.. tDQd#r=Io1Jdl+v4fobM=Y1KO2Z(IvloB:I}[p$2x9'OtW:Ea. But some people have been reluctant to take the drug since the CDC recommended that people with COVID rebounds start their isolation over again. <>/Font<>/XObject<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/Annots[ 9 0 R 10 0 R 31 0 R 32 0 R] /MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>>

There's little data yet on whether someone experiencing a COVID-19 rebound producesenough live virusto infect those around them. "Anecdotally, it seems like it's happening more frequently than what was reported to clinical trials.". All rights reserved. Gavin Newsom announced that California will become the first state in the nation to mandate students to have a COVID-19 vaccination in order to attend in person classes. The problem is personal for Dr. Robert Wachter,chairman of theDepartment of Medicineat the University of California, San Francisco, who conducted one of those surveys. Click here to sign up for our weekly coronavirus newsletter. For one, would rebound be as common in people who started the drug later, maybe on day four or five after their first symptoms, after their immune systems have had longer to initially see the virus? "Unless there were evidence that taking Paxlovid increased the risk of rebound and therefore led to higher length of needing to quarantine, which I don't think exists currently, there's no good reason for people to avoid taking Paxlovid if they fall into the risk categories of people who would benefit," Kuritzkes said. Complete and submit a MedWatch form, or complete and submit FDA Form 3500 (health professional) by fax (1-800-FDA-0178). The industry leader for online information for tax, accounting and finance professionals. Rebounding has happened throughout the pandemic, with people seemingly recovering from COVID-19, testing negativeand thenturning positive again or developing new symptoms about five days later,said Dr. Daniel Griffin,an infectious disease specialist at Northwell Health in New York. Charness and his co-authors have now collected at least 10 such cases of Covid-19 recurrence after Paxlovid. It's not clear whether a reboundafter taking the antiviral Paxlovid is any different than a rebound without the drug. People who have a Covid-19 rebound after treatment with the antiviral drug Paxlovid can be contagious and may not know it because they might not have symptoms, researchers warn. Reuters provides business, financial, national and international news to professionals via desktop terminals, the world's media organizations, industry events and directly to consumers. According the White House, over the past two months, filled prescriptions for Paxlovid have climbed from about 27,000 a week to 182,000 a week. "She was clearly recovering from the initial infection, was on the mend andthen had a new head cold set of symptoms on day 12," he said. You may be experiencing COVID-19 rebound if you have been diagnosed in the past 2 weeks and have recovred from COVID-19 and then experience recurrent COVID-19 symptoms or develop newly positive test results after recovery. "She felt crummy again.". What We Know About Mary Anderson, the Harvard, Mass., Woman Found Dead in Vermont, Ex-Boyfriend, Person of Interest in Harvard Woman's Death Had Violent Criminal Past, BA.5 COVID Symptoms: What Boston Doctors Say to Watch for. If you experience COVID-19 rebound, you should isolate again and restart the 5-day strict isolation period at the time of the recurrence in symptoms or new positive COVID-19 test result, It has been at least 5 days since the recurrence of symptoms or new positive test, Your symptoms are resolving and you have not had a fever for at least 24 hours (without the use of fever-reducing medications such as Tylenol), You should wear a mask for 10 days after rebound, If your rebound symptoms persist or worsen, you should contact your health care provider. BREAKING: Colorado Capitol building evacuated following bomb threat on Wednesday, Paxlovid users experiencing COVID rebound should isolate again for 5 days, CDC says, Kid lands massive tiger muskie on his first cast of the day at a Colorado reservoir, Serious crash closes part of Highway 24 northeast of Colorado Springs between Falcon and Peyton, Family shares powerful message after 4-year-old killed by falling tree in Colorado, Authorities find more than 20 pounds of drugs including meth hidden in a vehicle traveling through Colorado, Man charged in shooting mother while pushing baby in stroller, authorities say, Pressure on Senate GOP after same-sex marriage passes House, Colorado Capitol building evacuated following bomb threat on Wednesday. In another instance, a 63-year-old man infected two family members during three days of relapse after Paxlovid. <>/Metadata 132 0 R/ViewerPreferences 133 0 R>> She finally turned negative for good just recently, 18 days after first testing positive. And you know, we studied a small number of people. Experts said that rebounds don't necessarily mean Paxlovid doesn't work. Based on available data, it is not yet clear if the risk of infecting others is as high during the rebound period as it is during the initial infection period. Like most people, Hafner's second round of symptoms weren't severe, but it was a pain to have to wear a mask around the house for nearly three weeks, said Wachter, who never caught the virus. All quotes delayed a minimum of 15 minutes. He had taken a five-day course of Paxlovid and was feeling better. In such an event, individuals have reported finishing the five-day treatment, feeling better, and testing negative on an at-home rapid test. REUTERS/Jennifer Lorenzini. City Hall210 Main StreetNorthampton, MA 01060Phone: 413-587-4900. Discovery Company. (Gray News) - The Centers for Disease Control and Prevention is issuing a health advisory for people testing positive for COVID-19 after taking the antiviral treatment Paxlovid. Per CDC guidance, they can end their re-isolation period after 5 full days if fever has resolved for 24 hours (without the use of fever-reducing medication) and symptoms are improving. Limited information from case repoorts suggests that individuals treated with Paxlovid who experience COVID-19 rebound have had mild illness; there have been no reports of severe disease. Our Standards: The Thomson Reuters Trust Principles. The drug works well. "It may not be Paxlovid rebound, it may be COVID rebound, but we sure hear about it a lot.". The agency still continues to recommend the oral antiviral drug as a treatment, despite the possibility of recurrences. "We hadn't really heard about that from the clinical trial," Doron noted. CDC on Tuesday issued a warning saying that patients who complete a five-day course of Paxlovid and experience a return of Covid-19 symptoms should isolate for an additional five days, marking the first guidance the agency has issued on what patients should do if they test positive for Covid-19 days after testing negative. x][oH~7"dn cdhHdm[J;8EUuU]#~Uwb$>\R6MUq>y3+Wo\zSMQW#"R:H"A$Q_^qy2i 0a`b#' 1F Did you encounter any technical issues? For that reason, the CDC says, early treatment with this medication is still recommended. The antiviral drugs should be taken within the first few days of symptoms. The U.S. Justice Department unveiled a $1.2 billion healthcare fraud crackdown on Wednesday, revealing criminal charges against 36 defendants for alleged fraudulent billing schemes tied to telemedicine, genetic and cardiovascular testing, and equipment. I say, 'I don't know what the frequency of Paxlovid rebound is,' and we talk it out.". This study is still unpublished. California Gov. Based on this research, the US Centers for Disease Control and Prevention issued new guidance last week for people experiencing Covid-19 rebound after Paxlovid. The CDC said in its advisory that case reports suggest that recurrence results in mild symptoms, and there have been no reports of severe disease so far. Tuesday afternoon, he argued hismore nuanced support in 23 Tweets. Pfizer, which makes the drug, says rebounds studied in the real world closely reflect what happened in the trial. Here's what a new study suggests. read more. People who test positive for COVID-19 again after taking the drug Paxlovid should isolate for another five days, the Centers for Disease Control and Prevention said Tuesday. But then, their Covid-19 symptoms return, and they test positive again a few days later. Reporting by Manas Mishra in Bengaluru; Editing by Shailesh Kuber, U.S. announces $1.2 bln healthcare crackdown tied to telehealth, cardiovascular tests, Biogen leans on new Alzheimer's drug to calm investor worries, Japan health panel delays emergency approval of Shionogi COVID-19 pill, Merck's Keytruda fails head and neck cancer trial, Vaccine group invites African states to apply for malaria shot support, See here for a complete list of exchanges and delays. Although the guidance is specific to those taking Paxlovid, Hicks, chief medical officer of CDC's COVID-19 response, said anyone who tests positive or feels poorly again should stay away from others. The CDC reports Paxlovid treatment helps prevent hospitalization and death due to COVID, but COVID-19 rebound has been seen in those taking the drug between two and eight days after their initial recovery. We help leaders and future leaders in the health care industry work smarter and faster by providing provocative insights, actionable strategies, and practical tools to support execution. There have been reports of COVID-19 rebound occurring between 2 and 8 days after initial recovery from COVID-19. 7:49 AM EDT, Tue May 31, 2022, 'I'm losing my mind': Chinese depositor loses life savings in bank, LOS ANGELES, CALIFORNIA - APRIL 21: A man is asked to cough into his arm as part of testing for COVID-19, by a member of the Los Angeles Fire Department wearing personal protective equipment (PPE) in Skid Row, amidst the coronavirus pandemic on April 21, 2020 in Los Angeles, California. Advise people with COVID-19 rebound to follow CDCs guidance on isolation and take precautions to prevent further transmission. In studies of more than 2,200 Covid-19 patients, Pfizer, the company that makes the drug, said there were a few patients who had their Covid-19 come bouncing back after a negative test, but they were in the group that took Paxlovid as well as in those who got the placebo, suggesting that Covid just reappears in some people, even without treatment. Reuters, the news and media division of Thomson Reuters, is the worlds largest multimedia news provider, reaching billions of people worldwide every day. The patient initially took Paxlovid the day his symptoms began and was symptom-free two days later. Health and patient safety coverage at USA TODAY is made possible in part by a grant from the Masimo Foundation for Ethics, Innovation and Competition in Healthcare. The Masimo Foundation does not provide editorial input. Theres also no sign that the virus has changed or mutated to develop some kind of resistance to the drug. "If you ask too much from your patients, there's a point where they say, 'You know what, that's unreasonable,' and they don't do anything," he said. He said theyve found at least two instances in which people have transmitted to others when their infection recurs. The most comprehensive solution to manage all your complex and ever-expanding tax and compliance needs. Treatment helps prevent hospitalization and death due to COVID-19.Staying up-to-date on COVID-19 vaccinations is also recommended to lower risk of contracting COVID-19, and for preventing severe illness and hospitalizations., Please do not hesitate to reach out to a Waltham Public Health Nurse with any questions., City of Waltham, 610 Main Street, Waltham, MA 02452 (781) 314-3000Hours: 8:30 - 4:30, Monday through FridayWebsite Disclaimer Government Websites by CivicPlus , Waltham Community Access Corporation Board, current recommendations for isolation and masking, current isolation recommendations and mask, West Nile and EEE Protection / Information. Patients should re-isolate for at least 5 days. "For many people that really changes the risk-benefit, because for many people, it's the isolation that's one of the worst parts of having COVID," Doron said. On Tuesday, the health agency issued an advisory about the potential recurrence of COVID-19 or COVID-19 rebound in those treated with Paxlovid. "If we now start saying that everyone who has a couple more days of feeling crummy has to isolate again, it's going to be hard at this stage of the pandemic to get people not to just say, 'I'm not going to listen at all.'". The one study cited by the CDCwhich has not yet undergone peer review and reports on a single case where a rebounding patient passed on the virus is not enough to justify isolating vast numbers of people, Griffin said. "We're actually investigating that and trying to get more and more information.".

Tufts Medical Center's Dr. Shira Doron, Boston Medical Center's Dr. Sabrina Assoumou and Brigham and Women's Hospital's Dr. Daniel Kuritzkes shared what they've seen and what they tell their patients about whether or not to take Paxlovid during NBC10 Boston's latest"COVID Q&A"discussion. Korean language watermark on image as provided by source reads: "KCNA" which is the abbreviation for Korean Central News Agency. A recent rise in COVID cases has driven up use of therapeutics in the country. (Korean Central News Agency/Korea News Service via AP, File), 'Colossal miscalculation': How a North Korea parade likely led to explosive outbreak, NYC mayor rejects mask mandate amid high Covid-19 alert, SAN FRANCISCO, CALIFORNIA - OCTOBER 01: California Gov. Create an Account - Increase your productivity, customize your experience, and engage in information you care about. R c$k:i0rhWfK=(nfk\)`=77_5XpG3`Q,}#]|e,o}^ _F"j3K4{%ANgjvudqKWIwify83.=^fGW|oWx]G 2y{0Ahk%*5Da=" SG}|22\|AJy&A~)@h] % -Z?LTKL'R}JI5g 4T )"]*_^[;];[%b]e4(!8 CDC added that there's "currently no evidence that additional treatment is needed with Paxlovid or other anti-[coronavirus] therapies in cases where COVID-19 rebound is suspected" and noted that a return of symptoms may be part of the natural course of the coronavirus in patients, "independent of treatment with Paxlovid and regardless of vaccination status.". "It's this phenomenon that really started anecdotally with people reporting that they took Paxlovid -- they felt better, often immediately," Doron said. As omicron continues to surge throughout the country, constantly evolving information and regulatory guidance has made the already challenging task of communicating with stakeholders more difficult. Dump Truck Spills Wet Concrete on I-495, Causing Traffic Delays. Paxlovid is still the recommended treatment for mild-to-moderate COVID infection in individuals at high risk for severe disease, Recurrence of symptoms and/or a new positive test after having tested negative, Rebound occurs between 2 and 8 days after initial recovery. People take Paxlovid, and what we know it does very well is, it blocks viral replication, he said.

Half of them have come from just two families, leading the researchers to conclude that such cases are not all that rare. Charness said the fact that the infection can come back this way after treatment presents some questions. Published 2 0 obj Neither the baby nor its parents had any other close contacts before they got sick. Ask our experts a question on any topic in health care by visiting our member portal, AskAdvisory. The man was 12 days past his first positive Covid-19 test. So far, rebound cases have been mild. "If you get better and then you get worse again or if you decide to test and you have a test that's positive, especially after a negative test result, the recommendation is to re-isolate for at least five more days and continue masking for at least 10 more days," said Lauri Hicks, CMO of CDC's Covid-19 response. His wife, journalist Katie Hafner, tested positive for COVID for eight days, negative on days nine through 12 and positive again on day 13, he said. Opinion: Rebound after taking Paxlovid is the latest twist in the Covid-19 puzzle. Griffin said he's not convinced it's good public policy to recommend a second period of isolation. For further information on the use of Paxlovid, CDC recommends healthcare providers continue to closely follow NIHs COVID-19 Treatment Guidelines, the Assistant Secretary for Preparedness and Response Public Health Emergency COVID-19 Therapeutics site, and IDSAs Guidelines on the Management of Patients with COVID-19. Wachter also comes down on the side of taking Paxlovid, though a little more cautiously. Will taking ibuprofen or steroids lead to chronic pain? Thisincludes older adults and anyone 12 or older (weighing at least 88 pounds) who has amedical condition such as diabetes, asthma or immune issues. "The question becomes, is this rebound symptomatology and positive test a natural phenomenon of COVID-19 that we just really didn't recognize? Gavin Newsom tests positive for Covid-19. Get the latest news on COVID-19 delivered to you. There is currently no evidence that additional treatment for COVID-19 is needed for COVID-19 rebound. But anecdotal reports and decidedly unscientific Twitter surveys have found that as many as 47% of respondents who took Paxlovid say they went through a rebound. President Biden Talks Climate Change, Clean Energy in Mass. Somebody should be studying this.. Based on data available at this time, patient monitoring continues to be the most appropriate management for patients with recurrence of symptoms after completion of a treatment course of Paxlovid. Although this guidance is specific to those who rebound after taking Paxlovid, Hicks said anyone who tests positive or feels poorly again should stay away from others. For information on Paxlovid eligibility, refer to FDAs Fact Sheet for Healthcare Providers. Your effort and contribution in providing this feedback is much stream Independent journalists were not given access to cover the event depicted in this image distributed by the North Korean government. Copyright 2022 Gray Media Group, Inc. All rights reserved. The National Institutes of Health stillrecommends itover other treatments for mild or moderate COVID. Doron questioned whether the Paxlovid rebound is occurring more frequently due to a difference between delta, which was the predominant variant of coronavirus during the trial, and omicron, the only strain that's circulating now. (Photo by Justin Sullivan/Getty Images), Coronavirus disease (COVID-19) treatment pill Paxlovid is seen in boxes, at Misericordia hospital in Grosseto, Italy, February 8, 2022. All Rights Reserved. There havent been any reports of severe disease during a Covid-19 relapse. The mandate will go into effect at all private and public schools in the state when the FDA approves the vaccinations for students age and grade level. Use this resource with internal and external stakeholders to audit your omicron communication strategy and prepare your strategy moving forward. 2022 USA TODAY, a division of Gannett Satellite Information Network, LLC. Healthcare providers are encouraged to report cases of COVID-19 rebound to Pfizer after Paxlovid treatment using the following online tool: Pfizer Safety Reporting and to FDA MedWatch. According to the Associated Press, federal regulators have sent more precise guidance to physicians to help them determine how to manage Paxlovids interactions with other drugs, intending to help prescribers find ways to get the life-saving medication to more patients. The content of this image is as provided and cannot be independently verified. Its certainly conceivable that there are other people out there who dont have symptoms and still have a viral rebound.. endobj Contact a healthcare provider if your COVID-19 rebound symptoms persist or worsen. Since then, doctors and infectious disease experts in Boston have been flooded with questions from their patients about the drug, which was approved for people who have mild or moderate COVID but are at high risk of a severe case. Build the strongest argument relying on authoritative content, attorney-editor expertise, and industry defining technology. When researchers looked at 1,000 cases of Covid-19 diagnosed between December and March in players and support staff of the National Basketball Association who had not taken the drug, they didnt find any cases of Covid-19 returning. The baby tested positive about three days later, as did both of his parents. The patient should wear a mask for a total of 10 days after rebound symptoms started. They say more research is needed to understand whether there could be any connection to the drug. Genetic testing suggests that when people get a second round of Covid-19 after Paxlovid, its not because theyve been infected by a different strain of the virus. Symptom recurrence and COVID-19 rebound have been observed since the beginning of the pandemic, and may be part of the natural course of infection for some individuals. Consider clinical evaluation of patients who have COVID-19 rebound and symptoms that persist or worsen. (Photo by Joe Raedle/Getty Images), 'Broken system': Expert reacts to airlines pushing to end international traveler testing, Reality Check: The real cost of Covid-19 relief fraud, Pfizer CEO pledges vaccines to low-income countries at zero profit, Watch John Mulaney and Andy Samberg roast Jimmy Kimmel for getting Covid again, FILE - In this photo provided by the North Korean government, North Korean leader Kim Jong Un, center, visits a pharmacy in Pyongyang, North Korea on May 15, 2022. As helpful as it is, though, researchers say people should be aware the drug may not completely extinguish the infection. In addition, researchers did not identify any mutations that would suggest it had developed a resistance to Paxlovid. CDC recommends that patients with COVID rebound can end their re-isolation period after five full days if there is no fever for 24 hours and symptoms improve, but such patients should wear a mask for a total of 10 days after rebound symptoms begin. A preprint casestudyreported that a 71-year-old man, who was fully vaccinated and boosted, saw his virus rebound after taking Paxlovid. It's that they rebound and it seems like they start from the beginning, their virus goes way up," Siedner said. "It's a really unique phenomenon.". And so the levels of virus go down. A Warner Bros. All rights reserved, FIRST ALERT: Mass., NH Heat Wave Drags on, BA.4, BA.5 Subvariant COVID Cases Creeping Up' in New England: What to Know, COVID Infection Increases Risk of Psychiatric Diagnoses, Study Finds, Sign up for our News Headlines newsletter. Paxlovid should be considered for any patient who meets the eligibility criteria. As a result, health care leaders must clearly and efficiently communicate changing guidance and information about the state of the pandemic, rising case numbers, vaccine and booster availability, emerging treatments, internal policies, and more, with community members, patients, and staff. The findings and guidance come as Paxlovid use has increased in the United States. 2022 Cable News Network. Gavin Newsom speaks during a news conference after meeting with students at James Denman Middle School on October 01, 2021 in San Francisco, California. The Centers for Disease Control and Preventionissued in an advisory about the phenomenon last month. Dozens of individuals have reported rebounding COVID symptoms on social media or to the U.S. Food and Drug Administration after taking Paxlovid, but Pfizer suggests the experience is rare. It is characterized by a recurrence of COVID symptoms or a new positive viral test after testing negative. Re-isolation can be endedafter 5 full days if fever has resolved for 24 hours (without the use of fever-reducing medication) and symptoms are improving.. Charness and his colleagues recently collaborated with a team of researchers at Columbia University to look into cases of Covid-19 that return after Paxlovid treatment. Omicron subvariants will likely drive a new summer surge. Due to the potential for severe drug-drug interactions with the ritonavir component of Paxlovid, it is strongly suggested that healthcare providers not experienced in prescribing this drug refer to the Fact Sheet for Healthcare Providers, the Paxlovid Patient Eligibility Screening Checklist Tool for Prescribers, and the NIH Statement on Paxlovid Drug-Drug Interactions | COVID-19 Treatment Guidelines. But then in some people no one knows how many, because not enough people have been studied levels of the virus begin to climb again nine to 12 days after they first test positive, Charness said. "It's not just that they rebound. Copyright 2022 NBCUniversal Media, LLC. California Gov. 2022 Advisory Board. Daniel Griffin, an infectious disease specialist at Northwell Health, said he doesn't believe it's a good idea to recommend a second period of isolation, as some patients will still test positive on a rapid antigen test for more than two weeks after their diagnosis, despite research showing the majority of coronavirus transmissions occur within the first five days of infection. Some people continue to test positive on rapid antigen tests for more than two weeks after an initial diagnosis, but studies show that the vast majority of transmissions occur in the first five days of a COVID-19 infection, he said. The CDC recommends that individuals who experience COVID-19 rebound should follow current recommendations for isolation and masking regardless of treatment with an antiviral medication and/or previous isolation after an initial infection. Would a longer course of treatment maybe taking the drug for six or seven days, rather than five lower the risk that the virus would come back? Re-isolate for at least 5 days and wear a mask for a total of 10 days after rebound symptoms started. According to the CDC, available information suggests that people treated with Paxlovid who experience COVID-19 rebound have had a mild illness. However, after a week, he was sick once again, with his symptoms lasting for roughly four days the second time.

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